PSV Eindhoven were victorious against Vitesse Arnhem, while Sparta Rotterdam boosted their survival hopes with a win against fellow strugglers Heracles.
Ibrahim Afellay and Ola Toivonen were on target in a 2-0 win for the Dutch champions.
Edouard Duplan got the only goal in a 1-0 win for Sparta, as Heracles finished the match with only nine men. Defenders Mark Looms and Birger Maertens were both dismissed in the second half.
Elsewhere, NEC Nijmegen and Willem II finished goalless.