Arsenal are set to be without captain Cesc Fabregas again for the trip to Hull while Tomas Rosicky and Sol Campbell are both doubtful.
The Spain international picked up a hamstring injury in last week's victory over Burnley and, despite reports he could have been fit for Porto in midweek, he missed out as the Gunners ran out 5-0 winners.
Samir Nasri is set to continue his role in the centre of the park for Arsenal with manager Arsene Wenger claiming there is very little chance Fabregas will be fit for the trip to the KC Stadium.
"But [Fabregas'] chances of playing are 0.5 per cent - that means unless a miracle happens, he will not play. At the moment, he is out of Saturday's game," Wenger told the club's website.
Arsenal could also be without Tomas Rosicky after he picked up a problem against Porto while Sol Campbell and Bacary Sagna could miss the trip north through fatigue and an ankle injury respectively.
Arsenal are already without Robin van Persie, Kieran Gibbs, Aaron Ramsey and Johan Djourou while Wenger revealed on Friday that it could be a while before William Gallas returns to action after he broke down in training on his way back from a calf injury.
"Calves sometimes are a mystery. It came back twice. It's that the injury is much worse, it's that we have to be cautious with it. We pushed him a bit and he was in a hurry. But we have to be cautious this time, to take a little bit more time than we would do," he added.