Jan Vertonghen insists Tottenham are more than capable of ending their 23-year wait for a victory at Old Trafford.
Having revamped the Manchester United squad with the signings of Robin van Persie and Shinji Kagawa, Sir Alex Ferguson is desperate to win back the Barclays Premier League, and aside from an opening defeat at Everton the club have started the season strongly.
Tottenham's record - they have only taken four points on trips to face the Red Devils since Gary Lineker scored in their last win in 1989 - makes them big underdogs for the clash, but Vertonghen insists the Londoners can pull off an upset.
Vertonghen knows what it is like to taste victory at Old Trafford having won there last year in the Europa League with Ajax.
And with Spurs now seemingly finding their rhythm under new boss Andre Villas-Boas, the Belgian is hopeful about his team's chances of putting their Old Trafford hoodoo to bed.
"We are strong enough to beat them," Vertonghen said. "We have a good team, we've won the last two or three games now playing good football and everyone is hopeful of getting a good result at Old Trafford."