Phil Jagielka could make his first Everton start since April at Tottenham on Sunday as Phillipe Senderos picked up a knock in Lisbon.
Central defender Senderos was replaced by Jagielka during the second half of the 3-0 Europa League last-32 second leg defeat to Sporting on Thursday evening when he limped out of the action.
And, while Moyes will be disappointed to lose the services of Senderos if he is out of the White Hart Lane showdown, he is boosted by Jagielka's come back from a serious knee injury.
He said: "We do not think it is too serious regarding Senderos but we are not sure.
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It was good to have Jagielka back and he will help us towards the end of the season."
The Toffees have lost only one of their last 12 Premier League games, winning five of their last six, but will have to try and extend that run without the services of Tim Cahill, Marouane Fellaini and Tony Hibbert.