Mark Robins has doubts over Daniel Bogdanovic, Anderson De Silva, Filipe Teixeira and full-back Rob Kozluk for the clash with QPR.
The Barnsley boss is looking to end the season at home on a high with a win over QPR but he will have to give the quartet late fitness tests before deciding on whether they can feature or not.
"There are still a couple (of players) to run the rule over, we will probably have a better idea on Friday," Robins told the Sheffield Star.
"We don't have any new injury concerns going into this weekend, we pretty much have the same group of players again.
"
There are a lot of reasons why things have dropped off and some of that is down to the fact that this season has taken a lot out of the players
"But the last two performances have not been good enough. We have to change the perceptions and expectations of the players."