John Velazquez has been booked for the ride aboard Crowded House in the Dubai World Cup at Meydan later this month.
Jamie Spencer has ridden the four-year-old son of Rainbow Quest in all but two of his eight races, including his two runs at Meyden this season, but connections feel an American rider will prove invaluable in the dirt race.
"This is no reflection on Jamie and he will be riding Crowded House again when he returns to Europe," trainer Brian Meehan told his website.
"The World Cup is an American-style race run on an American-style track and connections feel that an American jockey would suit him better on this occasion."
Meehan has been delighted with the form of his Investec Derby sixth since his last run on February 18 and is looking forward to the ten furlong Group One on March 27.
"We did say that Crowded House would need both races and we were very pleased with him on each occasion," Meehan explained.
"We have had World Cup day as the target all along and we have been very happy with him since his last run.
"He is working very well and we are very happy with him and we are very confident."