Hibs are set to be without Sol Bamba, Darren McCormack, Kevin McBride and Chris Hogg against Hearts while Liam Miller is a major doubt.
Suspended trio Bamba, McCormack and McBride will sit out the final Edinburgh derby of the season, while skipper Hogg is sidelined with a back problem.
Midfielder Miller is rated as extremely doubtful after breaking down in training on Thursday - the former Celtic man has not played since the defeat at Hamilton on April 10 due to a calf injury.