Paddy Wallace will start at inside centre for Ulster against Leinster in the Magners League at the RDS on Sunday.
Wallace, fresh from Grand Slam glory with the Ireland squad, replaces Ian Whitten in Matt Williams’ first XV, while Tom Court comes in for Justin Fitzpatrick in the front row.
Stephen Ferris will miss the clash, after picking up an injury during the RBS 6 Nations.
South African Robbie Diack returns to the match-day squad for the clash, having been unavailable for the last four games due to injury.
Williams is relishing the challenge of facing second-placed Leinster in Dublin, commenting: "I think it's going to be a hard sell, Leinster haven't had a home game for a long time, just after the Grand Slam a lot of people want to see some rugby.
"It will be a great day, it's a day you want to play and a day you want to coach. There will be no shortage of passion or excitement.
"Just to get everyone back has been a great week for us, we want to go down and play for each other and play for the jersey, as will Leinster and when you get two teams that are passionate for it, you'll get a great game."
Williams knows his players will have to be on top of their game to get anything from the encounter on the capital's south side.
"I have asked the guys to make sure they turn up this week, if you don't turn up against a side like Leinster they'll kill you," he admitted.
"They play beautiful rugby and are very structured, they have a lot of systems they use and they are a very complex team which means they are hard to predict, and if a team is hard to predict it's hard to defend.
"We're a side that is going forward and they don't necessarily like playing us, so we have to turn up and make it awkward for them.
"I've only played Leinster once since being here and I was very unhappy with the way we turned up that day, we weren't as passionate and committed as we should have been."
Ulster: Clinton Schifcofske; Andrew Trimble, Darren Cave, Paddy Wallace, Simon Danielli; Ian Humphreys, Isaac Boss; Tom Court, Rory Best (capt), BJ Botha; Ed O'Donoghue, Ryan Caldwell; Matt McCullough, David Pollock, Chris Henry.
Replacements: Nigel Brady, Bryan Young, Carlo Del Fava, Robbie Diack, Cillian Willis, Ian Whitten, Timoci Nagusa.